Low anti-body titer cold stored O+ whole blood is an FDA licensed and AABB approved blood product for administration in emergency release situations when other blood products are unavailable and/or the patient’s blood type is unknown. It is the unit of blood drawn from the donor which has been tested like any other blood product and a preservative is added (just like any other blood product) so it contains the red cells, plasma, platelets and white cells from the donor just like it was when it was circulating in their veins.

Our study of our patients indicate that waiting until a patient gets to the hospital to give the first transfusion has a very high death rate (over 70%). Cold stored whole blood can safely provide oxygen carrying capacity and restore coagulation at the same time.

No. This was the only blood product available from the inception of blood transfusion into the 1970’s. Patient transfusion risks actually decrease since they are receiving a transfusion from one donor source instead of three.

Each bag contains roughly 520 cc of total volume. Equivalent to 1 unit of PRBCs and 1 FFP.

Cold stored whole blood contains plasma and platelets.

Logistics. The effective shelf life of platelets, the number one coagulation factor needed by bleeding trauma patients, is three days. Patients bleed whole blood; we replace it with whole blood.

No. It is also not leukocyte reduced.

Yes, it should be. It can be used through all FDA approved warming/infusion devices.

Yes. Platelet function in cold stored whole blood on day 35 is the same as platelet function in a regular unit on day 5 when it must be used or discarded.

In the traditional sense, no, because it is Rh+, not Rh-

Yes. The risk benefit to the patient favors risk of antibody formation versus death due to hemorrhage.

You should consult with your transfusion medicine and/or obstetrics expert.

Children under the age of three probably should not get emergency release whole blood due to the development of their immune system.

The same kind of reactions that can occur during transfusion of any blood product.

No. Administration is the same as with all other blood/blood products.

In small quantities, no. However, just as with any uncrossmatched, emergency release blood product, this issue can arise if the patient gets replacement of their full blood volume. It is typically not a life threatening condition.

Yes